Recreational marijuana has been legal in Colorado for some time, but that doesn’t mean the medicinal side of cannabis should be forgotten about. Many of us have already heard about CBD’s potential to destroy cancer cells, relieve chronic pain, and help your body run at its maximum potential, but few of us actually know which strains are high in CBD before visiting the dispensary. Here are 5 of the most popular CBD strains in Colorado. Each one provides a different set of effects, so read carefully to make sure you get the medicine most appropriate for your needs!

What’s CBD

The first thing that should be discussed is, of course, CBD and it’s medical benefits. CBD is a cannabinoid compound responsible for the treatment of a wide variety of physical ailments. Cannabidiol (CBD) is the most common cannabinoid found in marijuana, right behind THC (tetrahydrocannabinol), which is responsible for the cerebral and psychoactive properties of cannabis. CBD isn’t a psychoactive chemical, though. It offers relaxing effects that provide a wide array of medical uses, as well as health benefits that are useful even if you’re not chronically ill. CBD isn’t the chemical that gets you stoned so it’s an excellent choice for treating patients in need of pain relief, nausea, headaches, stress, anxiety, epilepsy, muscle spasms, and plenty of other ailments while keeping a level head.

Not all strains high in CBD are created equally, so it’s quite difficult to actually walk into your local pot shop and find a strain that’ll work best for you. The following strains are the most popular CBD strains with great reviews and medical benefits found in Colorado. They are typically easy to find too, so you won’t have to go too far to get them.


Harlequin is a popular strain in every state with a medical marijuana program. It’s a mild 75/25 Sativa-dominant hybrid that is a descendant of Colombian Gold, Nepali Indica, and Swiss Landrace. It typically tests in with a 5:2 ratio of CBD to THC. It comes with an alertness and a mild cerebral effect, but it won’t get you stoned out of your mind unless you’re smoking a ton. It comes with a happy feeling along with a mild euphoria that won’t make you give you that heart racey feeling or nervous because the large dose of CBD provides relaxing and calming effects. It’s sativa properties will also help you focus on whatever tasks you’re trying to accomplish throughout your day. It has a variety of flavors depending on how it’s grown, including an earthy musk to sweet mango flavors. Most patients and consumers in Colorado choose it to treat stress and chronic pain, due to its ability to help you relax without an indica heaviness.

Sweet and Sour Widow

Sweet and Sour Widow is a 70/30 Indica dominant hybrid with a balanced 1:1 CBD to THC ratio. It lies in the middle ground between strains with little THC to strains with an amount of THC that will give you a cerebral effect. Due to this perfect balance, even a first-time cannabis user will be able to enjoy the effects of both cannabinoids without becoming part of their couch. It’s great medicine because it provides the benefits of CBD along with the euphoric high feeling, keep in mind though that the psychoactive effects are still very mild, so you’ll be able to work and go on with your day without a foggy feeling. It tastes earthy and sweet and comes from a White Widow lineage, so it’s also great for treating anxiety and depression along with chronic pain, insomnia, fatigue, and stress. Smoking this high CBD strain will give you a nice body buzz, but also relax your muscles and help soothe the pain. Sweet and Sour Widow is a very popular CBD strain in Colorado and is a great strain for helping you enjoy your life pain-free.


ACDC is one of the best strains for high doses of CBD with lower amounts of THC. It’s closer to a true hybrid with a very slight sativa dominance and is a phenotype of Cannatonic, which we’ll cover later. This remarkable strain produces no psychoactive effects and has tested as high as 19% CBD, which is where many strains bred for THC content land. ACDC sits at a 20:1 CBD to THC ratio, which is quite remarkable. This CBD content helps patients in Colorado as well as most other states with medical marijuana programs relieve a wide variety of ailments, including tension, pain, anxiety, and the side effects of chemotherapy all without intoxication.


Cannatonic is a widely available and popular strain in Colorado dispensaries for its low THC content and high CBD content. Cannatonic is a cross between a female MK Ultra plant, and a G13 haze male and can have anywhere between a 5:1 CBD to THC ratio and a 1:1 ratio. Even though it rarely tests above 6% THC, it’ll still give you a short, mellow and happy high along with the uplifting and relaxing effects of the CBD –around 6 to 17 percent. Cannatonic is a premier medicinal strain that is most often used for pain relief and muscle spasms as well as migraines, depression, and anxiety among other things. This strain is very fragrant and tastes sweet and citrusy.


Pennywise is a well-known strain and is growing in popularity. It is known for being high in CBD but also balanced with THC. Pennywise is an Indica dominant hybrid bred from Jack the Ripper and Harlequin. If you’re familiar with the Stephen King book Pennywise, you’ll see where it gets its name: A killer clown. The strain is very earthy and comes with a sort of spiced coffee scent and a really earthy flavor. Pennywise is great for treating chronic pain, PTSD, stress, and anxiety as well as cancer symptoms. It’s got a 1:1 THC/CBD ratio and will provide you with a nice mild euphoric feeling in the head and a nice relaxed feeling in the body. It also provides mental clarity, so it’s a great strain to smoke under many circumstances.