At RIPE dispensary edibles are dosed in milligrams. For those of us who would smoke a bowl here and there, upon entry into the legalized reality, you suddenly must grapple with this fact. Sure, we’ve been buying weed in some hybridized state between grams and ounces for a while, yet the concept of how much weed you need for edibles comes down to differences in how we understand weight as a measure of effect.
In truth, seeing “10 milligrams” next to an edible is a poor indicator of how you will feel if the only other experience with marijuana you’ve had is smoking a joint with friends. To add to this, edibles can take longer to kick in.
Edibles vs. Smoking
Eating edibles is often seen as a different experience than smoking. The high from edibles is produced through digestive metabolism rather than absorption through the lungs. This means it transitions through the digestive system, being broken down to get into the blood rather than being applied immediately to the bloodstream via absorption through the lungs.
Let’s do the math
Calculating how much weed you need for edibles requires two things. First, you must know the recipe. Second, you have to understand how the effects manifest when absorbed through the digestive system. These two things will not only dictate how strong your edibles are, but they will also frame what you can expect to experience. Again, for those of us who are accustomed to smoking, vaporizing, or even using topical marijuana, the effects commonly happen sooner than with edibles. This, however, is not an understanding that translates to potency.
Potency and Percentages
The potency of marijuana is most commonly measured in percentages. If you are making edibles which you view in a measurement of milligrams, a conversion relating to potency percentages will have to be used before you can determine how much weed you need for edibles. It works like this:
As more and more states come online with medical or recreational marijuana programs, states are increasingly seeing it necessary to put the products through laboratory testing to determine (a) if pesticides which can be harmful were used and (b) the potency of the cannabinoids and/or terpenes available in your weed or weed product. This made it easier for everyone to understand how strong the weed is, but when it comes to making edibles, a percentage indicating potency effectively undermines the fact that edibles are measured in milligrams.
This perception makes it difficult to determine how much you’ll need to make a poten
t batch. Compounded with the American aversion to using the metric system, the process of determining potency as a percentage of weight can easily produce an edible with either too much or not enough.
One gram of marijuana is equal to 1,000 mg of marijuana. On average, you’ll likely find your weed is between 10-30% THC. While this varies plant to plant, the meaning of the percentage remains the same. If your plant shows a THC potency of 20%, this means 20% of the 1,000 mg is THC. Think about it like this:
1 gram = 1,000 milligrams
20% of 1,000 mg = 200 mg
Per gram, you have 200 mg of THC
When determining how much weed you need for edibles, translating percentages to milligrams will help you understand how strong your batch is. The next part is knowing your recipe and how to cook with marijuana. If your recipe can make 60 cookies, you now need to apply the milligram strength over that.
How do you decide how many milligrams you want per edible?
Bioavailability and First-pass Metabolism
Research has shown THC can be processed through the digestive system, where a phenomenon known as first-pass metabolism is at work. First-pass metabolism is how your body converts food or drugs into things that impact your health and wellbeing. From food, this means getting necessary nutrients into the bloodstream. For drugs, this means getting a drug into the bloodstream. Typically, this process of first pass metabolism limits how much of a substance is absorbed into the blood. This is known as bioavailability.
Research suggests the bioavailability of smoking weed means your body will absorb an average of 30% if you smoke it. Think about it like this:
1 gram = 1,000 mg
20% THC = 200 mg per gram
30% of 200 mg = 60 mg
In effect, this means per gram of marijuana you smoke, your body may only fully absorb 6% of it, which is also 30% of the available THC. When to comes to how much weed you need for edibles, the bioavailability of THC via the digestive system is commonly less. Yet, marijuana edibles are effective at 5 mg or 10 mg intervals, and even less if you see fit. So what is truly going on?
A Metabolite That Bends the Rule
THC, when taken through the digestive system, is more likely to be converted to a metabolite in the liver, which has an amplified availability in the blood. THC is mostly converted to 11-OH-THC in the liver, which research suggests is four times as available to the body, even with a lower bioavailability than when smoked (estimated between 6-10%). Think about it like this:
1 gram = 1,000 mg
20% THC = 200 mg THC
6% of 200 mg = 12 mg
12 *4 = 48 mg
In effect, when determining how much weed you need for edibles, this is the reason they feel more intense while having a lesser potency. This means for every 12 mg of edibles you consume, you can expect it to produce a biological effect equivalent to 48 mg, which is only 20% less than the effect you’d expect from smoking an entire gram.